Wildfire smoke emissions caused 41,380 excess deaths per year during 2011 to 2020. Rising temperatures could increase these U.S. deaths more than 70% by 2050. The economic cost with roughly 2 C of warming may exceed costs from all other climate-driven damages in the U.S. combined.
https://sustainability.stanford.edu/news/us-faces-rising-death-toll-wildfire-smoke-study-finds